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Research Unit on Renal, Cardiovascular and Geriatric Disease
University of Medicine and Pharmacy "Grigore T. Popa", Iasi
Short link:
https://eeris.eu/
ERIF-2000-000U-3731
276
Visits
The Research Unit on Renal, Cardiovascular and Geriatric Disease is based in the Internal Medicine, Nephrology and Geriatrics Department of the University of Medicine and Pharmacy "Gr. T. Popa" Iasi. The main research area is cardiovascular disease in renal and geriatric patients. Using the available infrastructure, patients can be assessed regarding fluid status (bioimpedance, ultrasound lung comets), endothelial dysfunction (laser doppler flow perfusion monitoring), functional statu...
Adrian
Covic
accovic@gmail.com
Professor, MD, PhD, FRCP
SCIENTIFIC TEAM
3
Mihai ONOFRIESCU
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Dimitrie SIRIOPOL
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Luminita VORONEANU
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Clinical Research Centres
RI Domain of activity
Translational Research Centres
RI Domain of activity
Biomedical Imaging Facilities
RI Domain of activity
Cardiovascular Research in Renal and Geriatric Patients
RI Domain of activity
Research Data Management Plan:
No information available
Access Policy to Research Infrastructure and Related Services:
No information available
Research Services
Assessment of Advanced Glycation End-Products (AGEs) by measuring the auto-fluorescence of the skin (Skin AF).
SERVICE DESCRIPTION:
The AGE Reader offers non-invasive, simple, and fast assessment of AGEs by measuring the auto-fluorescence of the skin (Skin AF). AGEs play a key role in the pathogenesis of many age-related diseases, such as diabetes, cardiovascular disease and renal failure. Thus AGE Reader offers a real time and non-invasive assessment of cardiovascular risk. The test is easily performed by placing the test person’s forearm on the AGE Reader instrument.
SERVICE PERSONS:
Mihai ONOFRIESCU
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Assessments of Arterial Stiffness and Endothelial Function Using Pulse Wave Analysis
SERVICE DESCRIPTION:
Using the SphygmoCor to illustrate the procedure (a typical setup is shown in Figure 2), PWA takes approximately 20 minutes to complete. Following at least 10 minutes supine rest, brachial artery systolic and diastolic blood pressures are measured in the nondominant arm and used to calibrate the PWA measurements taken on the radial artery. Radial artery waveforms are then recorded in duplicate. A high-fidelity tonometer is used to obtain pressure waveforms by applying gentle pressure over the nondominant radial artery and repositioning the device until the greatest pulse signal is detected. Data is collected directly into a personal computer, and recordings are assessed visually to ensure that the best possible recording is obtained. After 20 sequential waveforms are acquired, an averaged peripheral waveform is generated and a corresponding aortic waveform is derived (see Figure 3). When consecutive AIx@HR75 readings differ by more than 4%, a third reading is obtained, and the mean of the closest two readings is taken.
SERVICE PERSONS:
Luminita VORONEANU
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Laser Doppler Blood Perfusion Monitoring
SERVICE DESCRIPTION:
The PeriFlux System 5000 is the fifth generation of the Perimed PeriFlux instrument range for microvascular assessment. It is a com- pact, easy-to-use, multi-functional system that can incorporate up to four function units. The combination of tcpO2/CO2 and laser Doppler function units provides more information about tissue perfusion, oxygenation and metabolic function than the two methods individually. Low power laser light is transmitted to the tissue via a fiber optic probe. The returning light is processed and the relative number and velocity of the blood cells in the tissue are calcu- lated and presented as blood perfusion. Laser Doppler has been extensively used for tissue evaluation on skin and most other organs (see Perimed Literature Reference List, or PubMed). The technique has recently grown in importance in the diagno- sis and treatment of hypoxia and ischemia-related tissue disor- ders. Valuable information is provided for: Management of peripheral vascular disease, Diabetes treatment, Amputation level determination, Monitoring therapy, Plastic surgery (evaluation of flaps), Treatment of burns
SERVICE PERSONS:
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Bioimpedance assessment of fluid and nutritional status
SERVICE DESCRIPTION:
The BCM – Body Composition Monitor is designed to measure fluid status during haemodialysis or peritoneal dialysis for chronic kidney disease. It is more likely to be used in haemodialysis because this is a more common procedure. The device can be used in dialysis clinics or during home visits and is in addition to current clinical judgement of fluid status, which is based on symptoms, current medication, residual kidney function and blood pressure. The person being monitored lies down and electrodes are attached to 1 hand and 1 foot on the same side of the body. These electrodes are connected to the monitor and fluid status is measured. The process takes between 5 and 10 minutes.
SERVICE PERSONS:
Dimitrie SIRIOPOL
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Pulmonary congestion assessment by lung ultrasound
SERVICE DESCRIPTION:
Assessment of extravascular lung water is a challenging task for the clinical cardiologist and an elusive target for the echocardiographer. Recently, a new method was developed using echocardiography (with cardiac probes) of the lung. An increase in extravascular lung water-as assessed independently by chest computed tomography, chest x-ray, and thermodilution techniques-is mirrored by appearance of ultrasound lung comets (ULCs). ULCs consist of multiple comet tails originating from water-thickened interlobular septa and fanning out from the lung surface. The technique requires ultrasound scanning of the anterior right and left chest, from the second to the fifth intercostal space. It is simple (with a learning curve of < 10 examinations) and fast to perform (requiring < 3 minutes). ULC assessment is independent of the cardiac acoustic window, because the lung on the anterior chest is scanned. It requires very basic 2-D technology imaging, even without a second harmonic or Doppler. ULCs probably represent an ultrasonic equivalent of radiologic Kerley B-lines.
SERVICE PERSONS:
Dimitrie SIRIOPOL
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Research Equipment
AGE READER
CATALOG NAME:
DESCRIPTION:
The AGE Reader offers non-invasive, simple, and fast assessment of AGEs by measuring the auto-fluorescence of the skin (Skin AF). AGEs play a key role in the pathogenesis of many age-related diseases, such as diabetes, cardiovascular disease and renal failure. Thus AGE Reader offers a real time and non-invasive assessment of cardiovascular risk. The test is easily performed by placing the test person’s forearm on the AGE Reader instrument.
PRODUCER:
Diagnoptics Technologies B.V.
PRODUCTION YEAR:
2009
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
SphygmoCor device
CATALOG NAME:
DESCRIPTION:
Using the SphygmoCor to illustrate the procedure (a typical setup is shown in Figure 2), PWA takes approximately 20 minutes to complete. Following at least 10 minutes supine rest, brachial artery systolic and diastolic blood pressures are measured in the nondominant arm and used to calibrate the PWA measurements taken on the radial artery. Radial artery waveforms are then recorded in duplicate. A high-fidelity tonometer is used to obtain pressure waveforms by applying gentle pressure over the nondominant radial artery and repositioning the device until the greatest pulse signal is detected. Data is collected directly into a personal computer, and recordings are assessed visually to ensure that the best possible recording is obtained. After 20 sequential waveforms are acquired, an averaged peripheral waveform is generated and a corresponding aortic waveform is derived (see Figure 3). When consecutive AIx@HR75 readings differ by more than 4%, a third reading is obtained, and the mean of the closest two readings is taken.
PRODUCER:
AtCor Medical, Sydney, Australia
PRODUCTION YEAR:
2007
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
SphygmoCor CP system
CATALOG NAME:
UMF.IS 21252-1080
DESCRIPTION:
SphygmoCor technology is the gold standard for noninvasive measurement of central blood pressure. It has been featured in hundreds of published studies, and is used in leading medical centers and in pharmaceutical clinical trials worldwide. The SphygmoCor CP system acquires the patient’s radial pulse waveform through a measurement taken at the wrist, derives the blood pressure waveform at the ascending aorta and reports vital central blood pressure data.
PRODUCER:
www.atcormedical.com
PRODUCTION YEAR:
2012
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Download data sheet file (645.71 kb)
PeriFlux System 5000 Blood monitoring unit
CATALOG NAME:
UMF.IS 2262-651
DESCRIPTION:
The PeriFlux System 5000 is the fifth generation of the Perimed PeriFlux instrument range for microvascular assessment. It is a compact, easy-to-use, multi-functional system that can incorporate up to four function units. The combination of tcpO2/CO2 and laser Doppler function units provides more information about tissue perfusion, oxygenation and metabolic function than the two methods individually.
PRODUCER:
www.perimed-instruments.com/products/flap-monitoring
PRODUCTION YEAR:
2007
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Download data sheet file (509.53 kb)
BCM – Body Composition Monitor
CATALOG NAME:
DESCRIPTION:
BCM – Body Composition Monitor gives information about the individual fluid status: Overhydration, Urea distribution volume (V), Total body water, extracellular and intracellular water and the Nutritional Status: Lean Tissue Index (LTI), Fat Tissue Index (FTI), Body Cell Mass (BCM)
PRODUCER:
Fresenius Medical Care
PRODUCTION YEAR:
2007
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Download data sheet file (221.67 kb)
GE V-Scan Handheld Ultrasound
CATALOG NAME:
DESCRIPTION:
VScan is a “pocket-sized ultrasound”. It comes with a 4GB micro-SD card (you can substitute a larger card if you need) for image capture and one phased-array probe. It has preprogrammed presets for cardiac, abdominal and obstetrical scans and is advertised as also also being suitable for urology, peripheral vascular and pleural fluid/motion detection. Used in the research unit for lung ultrasound and assessment pulmonary congestion by measuring the number of ULC (ultrasound lung comets).
PRODUCER:
http://www3.gehealthcare.com/
PRODUCTION YEAR:
2013
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Phone:
0744502867
Fax:
+40.232.211.820
Universitatii
,
16
,
Iasi
700115
,
Iasi
Romania
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